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EMD-50150

Helical reconstruction
3.86 Å
EMD-50150
3D View Gallery
Deposition: 23/04/2024
Map released: 26/02/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-50150
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9f2l summary report (pdf.gz) Map and 9f2l FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the I923V MDA5-dsRNA filament with ADP-AlF4 bound and 73-degree helical twist

EMD-50150

Helical reconstruction
3.86 Å
EMD-50150
3D View Gallery
Deposition: 23/04/2024
Map released: 26/02/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Mouse MDA5 I923V in complex with double stranded RNA
Fitted models: 9f2l

Deposition Authors: Singh R , Herrero del Valle A, Modis Y
Molecular basis of autoimmune disease protection by MDA5 variants.
Singh R , Joiner JD , Herrero Del Valle A, Zwaagstra M, Jobe I, Ferguson BJ, van Kuppeveld FJM, Modis Y
(2025) Cell Rep , 44 , 115754 - 115754
PUBMED: 40450684
DOI: doi:10.1016/j.celrep.2025.115754
ISSN: 2211-1247