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EMD-50034
SARS-CoV-2 M protein dimer (short form) in complex with Fab-B and CIM-834
EMD-50034
Single-particle3.2 Å
Deposition: 05/04/2024Map released: 22/01/2025
Last modified: 16/04/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Mus musculus
Sample: SARS-CoV-2 M protein dimer (short form) in complex with Fab-B and CIM-834
Fitted models: 9exa
Deposition Authors: Debski-Antoniak OJ, Hurdiss DL
Sample: SARS-CoV-2 M protein dimer (short form) in complex with Fab-B and CIM-834
Fitted models: 9exa
Deposition Authors: Debski-Antoniak OJ, Hurdiss DL
A coronavirus assembly inhibitor that targets the viral membrane protein.
Laporte M ,
Jochmans D ,
Bardiot D,
Desmarets L ,
Debski-Antoniak OJ,
Mizzon G ,
Abdelnabi R ,
Leyssen P ,
Chiu W ,
Zhang Z,
Nomura N ,
Boland S,
Ohto U ,
Stahl Y ,
Wuyts J,
De Jonghe S ,
Stevaert A ,
van Hemert MJ,
Bontes BW ,
Wanningen P,
Groenewold GJM ,
Zegar A ,
Owczarek K ,
Joshi S,
Koukni M,
Arzel P,
Klaassen H,
Vanherck JC,
Vandecaetsbeek I,
Cremers N ,
Donckers K,
Francken T,
Van Buyten T,
Rymenants J ,
Schepers J,
Pyrc K ,
Hilgenfeld R,
Dubuisson J ,
Bosch BJ ,
Van Kuppeveld F,
Eydoux C ,
Decroly E ,
Canard B,
Naesens L ,
Weynand B ,
Snijder EJ ,
Belouzard S ,
Shimizu T ,
Bartenschlager R ,
Hurdiss DL ,
Marchand A,
Chaltin P,
Neyts J
(2025) Nature , 640 , 514 - 523
,
Jochmans D ,
Bardiot D,
Desmarets L ,
Debski-Antoniak OJ,
Mizzon G ,
Abdelnabi R ,
Leyssen P ,
Chiu W ,
Zhang Z,
Nomura N ,
Boland S,
Ohto U ,
Stahl Y ,
Wuyts J,
De Jonghe S ,
Stevaert A ,
van Hemert MJ,
Bontes BW ,
Wanningen P,
Groenewold GJM ,
Zegar A ,
Owczarek K ,
Joshi S,
Koukni M,
Arzel P,
Klaassen H,
Vanherck JC,
Vandecaetsbeek I,
Cremers N ,
Donckers K,
Francken T,
Van Buyten T,
Rymenants J ,
Schepers J,
Pyrc K ,
Hilgenfeld R,
Dubuisson J ,
Bosch BJ ,
Van Kuppeveld F,
Eydoux C ,
Decroly E ,
Canard B,
Naesens L ,
Weynand B ,
Snijder EJ ,
Belouzard S ,
Shimizu T ,
Bartenschlager R ,
Hurdiss DL ,
Marchand A,
Chaltin P,
Neyts J
(2025) Nature , 640 , 514 - 523
Grant Support:
- Innovative Medicines Initiative: 101005077 (Switzerland)
- Netherlands Organisation for Scientific Research (NWO): 184.034.014 (Netherlands)