EMD-49942

Single-particle
3.9 Å
EMD-49942
3D View Gallery
Deposition: 28/03/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49942
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9nyr summary report (pdf.gz) Map and 9nyr FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 24

EMD-49942

Single-particle
3.9 Å
EMD-49942
3D View Gallery
Deposition: 28/03/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 24
Fitted models: 9nyr

Deposition Authors: Collier P, Zheng X, Ford M, Weiss M, Aversa R, Chen D, Li K, Growney JD, Yang A, Sathappa M, Breitkopf SB, Enerson B, Sawant R, Su L, Howarth L, Liang T, Paul A, Sharma K, Williams J, Kwiatkowski NP
Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2.
Collier PN, Zheng X, Ford M, Weiss M, Chen D, Li K, Growney JD, Yang A, Sathappa M, Breitkopf SB, Enerson B, Liang T, Paul A, Sawant R, Su L, Aversa RJ, Howarth C, Sharma K, Williams J, Kwiatkowski NP
(2025) J Med Chem , 68 , 18407 - 18422
PUBMED: 40833690
DOI: doi:10.1021/acs.jmedchem.5c01160
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: