EMD-49941

Single-particle
2.86 Å
EMD-49941
3D View Gallery
Deposition: 28/03/2025
Map released: 29/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49941
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9nyp summary report (pdf.gz) Map and 9nyp FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of NVL bound the the MM927 inhibitor

EMD-49941

Single-particle
2.86 Å
EMD-49941
3D View Gallery
Deposition: 28/03/2025
Map released: 29/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, unidentified
Sample: NVL bound to MM927 inhibitor
Fitted models: 9nyp

Deposition Authors: Cruz VE , Erzberger JP

Optimized dibenzothiazepinones activate the impaired ribosome biogenesis checkpoint and trigger p53-dependent apoptosis by inhibiting the 60S assembly factor NVL
Guo HH , Tao Y , Cruz VE , Fang M, Khivansara V , Xie S, Leach A, Rivera-Cancel G , Barrows N , Williams N , Aurora A , Erzberger JP , De Brabander JK , Nijhawan D
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