EMD-49896
Single-particle cryo-EM structure of the first variant of mobilized colistin resistance (MCR-1) in its ligand-bound state
EMD-49896
Single-particle3.58 Å
Deposition: 24/03/2025Map released: 17/12/2025
Last modified: 17/12/2025
Sample Organism:
Escherichia coli,
Homo sapiens
Sample: PE- and KLA-bound MCR-1 complex with Fab fragment
Fitted models: 9nww
Deposition Authors: Zinkle AP, Bunuro-Batista M, Herrera CM
,
Erramilli SK ,
Kloss B ,
Ashraf KU ,
Nosol K,
Zhang G,
Cater RJ,
Marty MT ,
Kossiakoff AA ,
Trent MS ,
Nygaard R ,
Stansfeld PJ ,
Mancia F
Sample: PE- and KLA-bound MCR-1 complex with Fab fragment
Fitted models: 9nww
Deposition Authors: Zinkle AP, Bunuro-Batista M, Herrera CM
,
Erramilli SK ,
Kloss B ,
Ashraf KU ,
Nosol K,
Zhang G,
Cater RJ,
Marty MT ,
Kossiakoff AA ,
Trent MS ,
Nygaard R ,
Stansfeld PJ ,
Mancia F
Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1.
Zinkle AP,
Batista MB,
Herrera CM ,
Erramilli SK ,
Kloss B ,
Ashraf KU ,
Nosol K,
Zhang G,
Cater RJ,
Marty MT ,
Kossiakoff AA ,
Trent MS ,
Nygaard R ,
Stansfeld PJ ,
Mancia F
(2025) Nat Commun , 16 , 10516 - 10516
,
Erramilli SK ,
Kloss B ,
Ashraf KU ,
Nosol K,
Zhang G,
Cater RJ,
Marty MT ,
Kossiakoff AA ,
Trent MS ,
Nygaard R ,
Stansfeld PJ ,
Mancia F
(2025) Nat Commun , 16 , 10516 - 10516
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM132120 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI181556 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI74416 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI176776 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI150098 (United States)