EMD-49893

Single-particle
2.7 Å
EMD-49893
3D View Gallery
Deposition: 24/03/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49893
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9nwt summary report (pdf.gz) Map and 9nwt FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of DDB1dB:CRBN:mezigdomide:SALL4(392-449;G416A)

EMD-49893

Single-particle
2.7 Å
EMD-49893
3D View Gallery
Deposition: 24/03/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of DDB1dB:CRBN:mezigdomide:SALL4(392-449;G416A)
Fitted models: 9nwt

Deposition Authors: Park J, Hunkeler M, Roy Burman SS , Fischer ES
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.
Slabicki M, Park J, Nowak RP, Roy Burman SS , Pellman J, Zou C, Razumkov H, Carreiro J, Rastogi S, Goldstein A, Nagiec MM, Donovan KA, Che J, Hunkeler M, Geng Q, Hsu CL, Lakshminarayan M, Shu C, Zon RL, Kozicka Z , Park PMC, Tsai JM, Yoon H, Jones LH , Sperling AS, Gray NS , Fischer ES, Ebert BL
(2025) Mol Cell , 85 , 3184 - 3201.e14
PUBMED: 40845806
DOI: doi:10.1016/j.molcel.2025.07.019
ISSN: 1097-2765
ASTM: MOCEFL