EMD-49745

Single-particle
3.3 Å
EMD-49745
3D View Gallery
Deposition: 16/03/2025
Map released: 25/06/2025
Last modified: 13/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49745

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ns9 summary report (pdf.gz) Map-9ns9 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of Gi-coupled FFA2 in complex with TUG-1375 and compound 187

EMD-49745

Single-particle
3.3 Å
EMD-49745
3D View Gallery
Deposition: 16/03/2025
Map released: 25/06/2025
Last modified: 13/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: TUG-1375-compound 187-FFA2-Gi complex
Fitted models: 9ns9

Deposition Authors: Zhang X , Tikhonova I, Milligan G , Zhang C
Allosteric modulation and biased signalling at free fatty acid receptor 2.
Zhang X , Guseinov AA , Jenkins L , Valentini A, Marsango S, Schultz-Knudsen K, Ulven T , Rexen Ulven E , Tikhonova IG , Milligan G , Zhang C
(2025) Nature , 643 , 1428 - 1438
PUBMED: 40533560
DOI: doi:10.1038/s41586-025-09186-6
ISSN: 1476-4687
ASTM: NATUAS