EMD-49601

Helical reconstruction
2.4 Å
EMD-49601
3D View Gallery
Deposition: 10/03/2025
Map released: 11/02/2026
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49601

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9non summary report (pdf.gz) Map-9non FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of amyloid fibril isolated from the kidney of a variant Alect2-I40V amyloidosis patient

EMD-49601

Helical reconstruction
2.4 Å
EMD-49601
3D View Gallery
Deposition: 10/03/2025
Map released: 11/02/2026
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Leukocyte cell-derived chemotaxin-2 protein
Fitted models: 9non

Deposition Authors: Nguyen B, Saelices L
Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM.
Afrin S, Nguyen BA , Singh V, Singh P, Bassett P, Pekala M, Evers B, Lopez C, Ahmed Y, Li L, Kallem RR, Lemoff A, Argyropoulos C, Kluve-Beckerman B, Saelices L
(2026) Nat Commun , 17
PUBMED: 41965342
DOI: doi:10.1038/s41467-026-71223-3
ISSN: 2041-1723