EMD-49573
Cryo-EM structure of a de-novo designed binder NY1-B04 in complex with HLA-A*02:01 and NY-ESO-1-derived peptide SLLMWITQC
EMD-49573
Single-particle3.8 Å
Deposition: 05/03/2025Map released: 23/07/2025
Last modified: 06/08/2025
Sample Organism:
Homo sapiens,
Bacillus subtilis,
synthetic construct,
Escherichia coli
Sample: de-novo designed binder NY1-B04 in complex with HLA-A*02:01 and NY-ESO-1-derived peptide SLLMWITQC
Fitted models: 9nnf
Deposition Authors: Gharpure A
,
Fernandez-Quintero ML ,
Ward AB
Sample: de-novo designed binder NY1-B04 in complex with HLA-A*02:01 and NY-ESO-1-derived peptide SLLMWITQC
Fitted models: 9nnf
Deposition Authors: Gharpure A
,
Fernandez-Quintero ML ,
Ward AB
De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.
Johansen KH ,
Wolff DS ,
Scapolo B ,
Fernandez-Quintero ML ,
Risager Christensen C ,
Loeffler JR ,
Rivera-de-Torre E ,
Overath MD ,
Kjaergaard Munk K ,
Morell O ,
Viuff MC ,
Lacunza I ,
Damm Englund AT ,
Due M ,
Gharpure A ,
Forli S ,
Rodriguez Pardo C ,
Tamhane T ,
Qingjie Andersen E,
Haldrup Bjornsson K,
Fernandes JS ,
Voss LF ,
Thumtecho S ,
Ward AB ,
Ormhoj M ,
Reker Hadrup S ,
Jenkins TP
(2025) Science , 389 , 380 - 385
,
Wolff DS ,
Scapolo B ,
Fernandez-Quintero ML ,
Risager Christensen C ,
Loeffler JR ,
Rivera-de-Torre E ,
Overath MD ,
Kjaergaard Munk K ,
Morell O ,
Viuff MC ,
Lacunza I ,
Damm Englund AT ,
Due M ,
Gharpure A ,
Forli S ,
Rodriguez Pardo C ,
Tamhane T ,
Qingjie Andersen E,
Haldrup Bjornsson K,
Fernandes JS ,
Voss LF ,
Thumtecho S ,
Ward AB ,
Ormhoj M ,
Reker Hadrup S ,
Jenkins TP
(2025) Science , 389 , 380 - 385
Grant Support: