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EMD-49362
Structure of the cross-HLA supertype antibody R302 bound to a class I MHC presenting a divarasib-modified KRAS-G12C peptide on HLA-A*03
EMD-49362
Single-particle2.58 Å
Deposition: 21/02/2025Map released: 08/10/2025
Last modified: 08/10/2025
Sample Organism:
Homo sapiens
Sample: Binary complex of Fab R302 with divarasib-conjugated KRAS G12C peptide (7-16) presented by class I MHC having HLA-A*03:01
Fitted models: 9nfc
Deposition Authors: Maso L
Sample: Binary complex of Fab R302 with divarasib-conjugated KRAS G12C peptide (7-16) presented by class I MHC having HLA-A*03:01
Fitted models: 9nfc
Deposition Authors: Maso L
Engineered antibodies that stabilize drug-modified KRASG12C neoantigens enable selective and potent cross-HLA immunotherapy
Maso L ,
Mosure SA ,
Rodriguez-Aponte SA ,
Pizzo A,
Mensah DN ,
Southard M,
Sze S ,
Vash B ,
Hattori T ,
Rajak E ,
Koide A ,
Neel BG ,
Koide S ,
Liu W ,
Toenjes ST ,
DaSilva-Jardine P,
Chopra R ,
Rader C ,
Stopfer LE
To Be Published
,
Mosure SA ,
Rodriguez-Aponte SA ,
Pizzo A,
Mensah DN ,
Southard M,
Sze S ,
Vash B ,
Hattori T ,
Rajak E ,
Koide A ,
Neel BG ,
Koide S ,
Liu W ,
Toenjes ST ,
DaSilva-Jardine P,
Chopra R ,
Rader C ,
Stopfer LE
To Be Published
Grant Support: