EMD-49300

Single-particle
3.53 Å
EMD-49300
3D View Gallery
Deposition: 19/02/2025
Map released: 04/06/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49300

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ne7 summary report (pdf.gz) Map-9ne7 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human polymerase epsilon bound to PCNA and DNA with an in-situ-generated mismatch in the Pol-backtracking state

EMD-49300

Single-particle
3.53 Å
EMD-49300
3D View Gallery
Deposition: 19/02/2025
Map released: 04/06/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Ternary complex of human DNA polymerase epsilon with PCNA and the mismatched DNA
Fitted models: 9ne7

Deposition Authors: Wang F , He Q, Li H
The proofreading mechanism of the human leading-strand DNA polymerase epsilon holoenzyme.
Wang F , He Q, O'Donnell ME , Li H
(2025) PNAS , 122 , e2507232122 - e2507232122
PUBMED: 40440070
DOI: doi:10.1073/pnas.2507232122
ISSN: 1091-6490
ASTM: PNASA6