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EMD-49201
Cryo-EM structure of 110_C4 Fab in complex with CIDRa1.7 PfEMP1
EMD-49201
Single-particle3.4 Å
Deposition: 12/02/2025Map released: 27/08/2025
Last modified: 27/08/2025
Sample Organism:
Homo sapiens,
Plasmodium falciparum
Sample: Complex of human serum antibody 110_C4 with CIDRa1.7 PfEMP1
Fitted models: 9naq
Deposition Authors: Raghavan SSR
,
Ward AB
Sample: Complex of human serum antibody 110_C4 with CIDRa1.7 PfEMP1
Fitted models: 9naq
Deposition Authors: Raghavan SSR
,
Ward AB
Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.
Turner L ,
Nunez de Villavicencio Diaz T ,
Raghavan SSR ,
Kana IH ,
Lyimo E ,
Reitzel C ,
Wang CW ,
Berube E,
Jensen RW,
Loeffler JR,
Fernandez-Quintero ML,
Theander TG ,
Lusingu JPA,
Le Bihan T ,
Han X,
Minja DTR ,
Ward AB ,
Ma B ,
Lavstsen T
(2025) PNAS , 122 , e2508744122 - e2508744122
,
Nunez de Villavicencio Diaz T ,
Raghavan SSR ,
Kana IH ,
Lyimo E ,
Reitzel C ,
Wang CW ,
Berube E,
Jensen RW,
Loeffler JR,
Fernandez-Quintero ML,
Theander TG ,
Lusingu JPA,
Le Bihan T ,
Han X,
Minja DTR ,
Ward AB ,
Ma B ,
Lavstsen T
(2025) PNAS , 122 , e2508744122 - e2508744122
Grant Support:
- Bill & Melinda Gates Foundation: (United States)
- Novo Nordisk Foundation: (Denmark)