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EMD-48922
Endogenous Pfs230D13-14 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44
EMD-48922
Single-particle3.39 Å
Deposition: 04/02/2025Map released: 15/10/2025
Last modified: 26/11/2025
Sample Organism:
Homo sapiens,
Plasmodium falciparum
Sample: Endogenous Pfs230 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44
Fitted models: 9n5i
Deposition Authors: Hailemariam S, Heide F, Bekkering E, Ivanochko D, Yoo R, Julien JP
Sample: Endogenous Pfs230 in complex with Pfs48/45 bound to anti-Pfs48/45 Fabs RUPA-71 and RUPA-44
Fitted models: 9n5i
Deposition Authors: Hailemariam S, Heide F, Bekkering E, Ivanochko D, Yoo R, Julien JP
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity.
Bekkering ET 
,
Yoo R,
Hailemariam S,
Heide F,
Ivanochko D,
Jackman M,
Proellochs NI,
Stoter R,
van Gemert GJ,
Maeda A,
Yuguchi T,
Wanders OT,
van Daalen RC,
Inklaar MR,
Andrade CM ,
Jansen PWTC,
Vermeulen M,
Bousema T,
Takashima E,
Rubinstein JL,
Kooij TWA,
Jore MM,
Julien JP
(2025) Immunity , 58 , 2899
,
Yoo R,
Hailemariam S,
Heide F,
Ivanochko D,
Jackman M,
Proellochs NI,
Stoter R,
van Gemert GJ,
Maeda A,
Yuguchi T,
Wanders OT,
van Daalen RC,
Inklaar MR,
Andrade CM ,
Jansen PWTC,
Vermeulen M,
Bousema T,
Takashima E,
Rubinstein JL,
Kooij TWA,
Jore MM,
Julien JP
(2025) Immunity , 58 , 2899
Grant Support: