EMD-48846

Single-particle
2.72 Å
EMD-48846
3D View Gallery
Deposition: 30/01/2025
Map released: 28/05/2025
Last modified: 10/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48846

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9n36 summary report (pdf.gz) Map-9n36 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure Of Respiratory Syncytial Virus Polymerase with novel non-nucleoside inhibitor compound 22

EMD-48846

Single-particle
2.72 Å
EMD-48846
3D View Gallery
Deposition: 30/01/2025
Map released: 28/05/2025
Last modified: 10/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: human respiratory syncytial virus
Sample: CryoEM map of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor compound 22
Fitted models: 9n36

Deposition Authors: Yin Y , Yu X, Kalin JH , Tran MT, Sharma S
Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
Kalin JH , Yin Y , Tran MT, Piassek M, Fung A, Grosse S, Jacoby E, Bhaumik A, Adhikary S, Miller R, Lemmens C, Lutter FH, Pieters S, Cooymans L, Rombouts G, Oehlrich D, Tomaso S, Lozada K, Garcia MO, Anson B, De Bruyn S, Smith-Monroy C, Neefs J-M, Conceicao-Neto N, Stoops B, van Vlijmen H, Patrick A, Yu X, Wong V, Krosky D, Abeywickrema P, Mason S, Jin Z, Jonckers THM, Sharma S
(2025) J Virol , 99 , e0017825 - e0017825
PUBMED: 40454903
DOI: doi:10.1128/jvi.00178-25
ISSN: 1098-5514
ASTM: JOVIAM
Grant Support: