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EMD-48846
CryoEM structure Of Respiratory Syncytial Virus Polymerase with novel non-nucleoside inhibitor compound 22
EMD-48846
Single-particle2.72 Å
Deposition: 30/01/2025Map released: 28/05/2025
Last modified: 10/12/2025
Sample Organism:
human respiratory syncytial virus
Sample: CryoEM map of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor compound 22
Fitted models: 9n36
Deposition Authors: Yin Y
,
Yu X,
Kalin JH ,
Tran MT,
Sharma S
Sample: CryoEM map of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor compound 22
Fitted models: 9n36
Deposition Authors: Yin Y
,
Yu X,
Kalin JH ,
Tran MT,
Sharma S
Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
Kalin JH ,
Yin Y ,
Tran MT,
Piassek M,
Fung A,
Grosse S,
Jacoby E,
Bhaumik A,
Adhikary S,
Miller R,
Lemmens C,
Lutter FH,
Pieters S,
Cooymans L,
Rombouts G,
Oehlrich D,
Tomaso S,
Lozada K,
Garcia MO,
Anson B,
De Bruyn S,
Smith-Monroy C,
Neefs J-M,
Conceicao-Neto N,
Stoops B,
van Vlijmen H,
Patrick A,
Yu X,
Wong V,
Krosky D,
Abeywickrema P,
Mason S,
Jin Z,
Jonckers THM,
Sharma S
(2025) J Virol , 99 , e0017825 - e0017825
,
Yin Y ,
Tran MT,
Piassek M,
Fung A,
Grosse S,
Jacoby E,
Bhaumik A,
Adhikary S,
Miller R,
Lemmens C,
Lutter FH,
Pieters S,
Cooymans L,
Rombouts G,
Oehlrich D,
Tomaso S,
Lozada K,
Garcia MO,
Anson B,
De Bruyn S,
Smith-Monroy C,
Neefs J-M,
Conceicao-Neto N,
Stoops B,
van Vlijmen H,
Patrick A,
Yu X,
Wong V,
Krosky D,
Abeywickrema P,
Mason S,
Jin Z,
Jonckers THM,
Sharma S
(2025) J Virol , 99 , e0017825 - e0017825
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