EMD-48718

Single-particle
3.85 Å
EMD-48718
3D View Gallery
Deposition: 20/01/2025
Map released: 10/09/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48718

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mxq summary report (pdf.gz) Map-9mxq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 Homodimer

EMD-48718

Single-particle
3.85 Å
EMD-48718
3D View Gallery
Deposition: 20/01/2025
Map released: 10/09/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Human immunodeficiency virus 1
Sample: Human immunodeficiency virus 1
Fitted models: 9mxq

Deposition Authors: Hollander K , Devarkar SC, Tang S , Ma S, Xiong Y, Anderson KS
Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Hollander K , Devarkar SC, Tang S , Tiwari R , Ma S, Lee WG, Denn E, Wang Q, Spasov KA, Robbins JA, Frey KM , Jorgensen WL, Xiong Y, Shan L, Anderson KS
(2025) Npj Drug Discov , 2 , 22 - 22
PUBMED: 40904837
DOI: doi:10.1038/s44386-025-00025-2
ISSN: 3005-1452