EMD-48523
RM017 Fab in complex with Apex-GT6.2 trimer and RM20A3 Fab
EMD-48523
Single-particle3.3 Å
Deposition: 03/01/2025Map released: 06/08/2025
Last modified: 03/09/2025
Sample Organism:
Macaca mulatta,
Human immunodeficiency virus 1
Sample: RM017 Fab in complex with Apex GT6.2 and RM20A3 Fab
Fitted models: 9mqg
Deposition Authors: Pratap PP, Ozorowski G
,
Ward AB
Sample: RM017 Fab in complex with Apex GT6.2 and RM20A3 Fab
Fitted models: 9mqg
Deposition Authors: Pratap PP, Ozorowski G
,
Ward AB
HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Ma KM ,
Sutton HJ ,
Pratap PP,
Steichen JM ,
Carnathan D,
Quinn J ,
Kalyuzhniy O ,
Liguori A ,
Agrawal S ,
Baboo S ,
Madden P,
Cottrell CA ,
Willis JR ,
Lee JH ,
Landais E ,
Hu X ,
Ramezani-Rad P ,
Ozorowski G ,
Lewis VR,
Diedrich JK ,
Zhou X ,
Altheide TK,
Phelps N ,
Georgeson E ,
Alavi NB,
Lu D ,
Eskandarzadeh S ,
Kubitz M,
Adachi Y ,
Mullen TM ,
Silva M,
Melo MB ,
Himansu S ,
Irvine DJ ,
Burton DR ,
Yates 3rd JR ,
Paulson JC ,
Sok D ,
Wilson IA ,
Silvestri G ,
Ward AB ,
Crotty S ,
Schief WR
(2025) Sci Immunol , 10 , eadt6660 - eadt6660
,
Sutton HJ ,
Pratap PP,
Steichen JM ,
Carnathan D,
Quinn J ,
Kalyuzhniy O ,
Liguori A ,
Agrawal S ,
Baboo S ,
Madden P,
Cottrell CA ,
Willis JR ,
Lee JH ,
Landais E ,
Hu X ,
Ramezani-Rad P ,
Ozorowski G ,
Lewis VR,
Diedrich JK ,
Zhou X ,
Altheide TK,
Phelps N ,
Georgeson E ,
Alavi NB,
Lu D ,
Eskandarzadeh S ,
Kubitz M,
Adachi Y ,
Mullen TM ,
Silva M,
Melo MB ,
Himansu S ,
Irvine DJ ,
Burton DR ,
Yates 3rd JR ,
Paulson JC ,
Sok D ,
Wilson IA ,
Silvestri G ,
Ward AB ,
Crotty S ,
Schief WR
(2025) Sci Immunol , 10 , eadt6660 - eadt6660
Grant Support:
- Bill & Melinda Gates Foundation: INV-002916 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): UM1 AI144462 (United States)