EMD-48496

Single-particle
3.66 Å
EMD-48496
3D View Gallery
Deposition: 29/12/2024
Map released: 08/10/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48496

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mp0 summary report (pdf.gz) Map-9mp0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

The cryo-EM structure of the human DNA methyltransferases DNMT3A2 and DNMT3L dodecamer

EMD-48496

Single-particle
3.66 Å
EMD-48496
3D View Gallery
Deposition: 29/12/2024
Map released: 08/10/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human DNA (cytosine-5)-methyltransferases DNMT3A2 and DNMT3L dodecamer
Fitted models: 9mp0

Deposition Authors: Yan Y , Zhou XE, Xu TH
Mechanisms of DNMT3A-3L-mediated de novo DNA methylation on chromatin.
Yan Y , Zhou XE, Thomas SL , Liu M , Lai GQ, Worden EJ , Jones PA , Xu TH
(2026) Nat Struct Mol Biol , 33 , 171 - 183
PUBMED: 41174279
DOI: doi:10.1038/s41594-025-01704-4
ISSN: 1545-9985