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EMD-48380

Single-particle
3.4 Å
EMD-48380
3D View Gallery
Deposition: 19/12/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48380
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9mlv summary report (pdf.gz) Map and 9mlv FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of acid-sensing ion channel 5 without calcium, closed

EMD-48380

Single-particle
3.4 Å
EMD-48380
3D View Gallery
Deposition: 19/12/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Acid-sensing ion channel 5 without calcium
Fitted models: 9mlv

Deposition Authors: Freitas MM, Gouaux E
The bile acid-sensitive ion channel is gated by Ca 2+ -dependent conformational changes in the transmembrane domain.
Freitas MM, Gouaux E
(2025) Nat Commun , 16 , 6746 - 6746
PUBMED: 40695804
DOI: doi:10.1038/s41467-025-62038-9
ISSN: 2041-1723
Grant Support:
  • National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): F31NS120713 (United States)
  • National Science Foundation (NSF, United States): 1000271223 (United States)
  • Howard Hughes Medical Institute (HHMI): (United States)
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