EMD-48339

Single-particle
3.68 Å
EMD-48339
3D View Gallery
Deposition: 18/12/2024
Map released: 11/02/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48339
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9mkv summary report (pdf.gz) Map and 9mkv FULL report (pdf.gz)
EMICSS annotations (xml)

FnoCas12a bridge helix variant state 3

EMD-48339

Single-particle
3.68 Å
EMD-48339
3D View Gallery
Deposition: 18/12/2024
Map released: 11/02/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Francisella tularensis subsp. novicida U112
Sample: Ternary complex of FnoCRISPR-Cas12a
Fitted models: 9mkv

Deposition Authors: Ganguly C , Thomas LM , Aribam SD , Martin L, Rajan R
Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation.
Ganguly C , Aribam SD , Dos Santos AM , Martin L, Thomas LM , Shao Y, Rajan R
(2026) Nat Commun , 17
PUBMED: 41605928
DOI: doi:10.1038/s41467-026-68657-0
ISSN: 2041-1723