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EMD-48289
Cryo-EM structure of Human NLRP3 complex with compound 3
EMD-48289
Single-particle3.6 Å
Deposition: 12/12/2024Map released: 26/02/2025
Last modified: 12/03/2025
Sample Organism:
Homo sapiens
Sample: NLRP3 hexamer
Fitted models: 9mig
Deposition Authors: Mammoliti O
,
Carbajo RJ,
Perez-Benito L,
Yu X,
Prieri MLC ,
Bontempi L,
Embrechts S,
Paesmans I,
Bassi M,
Bhattacharya A,
Roman SC,
Hoog SD,
Demin S ,
Gijsen HJM ,
Hache G,
Jacobs T,
Jerhaoui S ,
Leenaerts J,
Lutter FH,
Matico R,
Oehlrich D ,
Perrier M,
Ryabchuk P ,
Schepens W,
Sharma S,
Somers M,
Suarez J,
Surkyn M,
Opdenbosch NV,
Verhulst T,
Bottelbergs A
Sample: NLRP3 hexamer
Fitted models: 9mig
Deposition Authors: Mammoliti O
,
Carbajo RJ,
Perez-Benito L,
Yu X,
Prieri MLC ,
Bontempi L,
Embrechts S,
Paesmans I,
Bassi M,
Bhattacharya A,
Roman SC,
Hoog SD,
Demin S ,
Gijsen HJM ,
Hache G,
Jacobs T,
Jerhaoui S ,
Leenaerts J,
Lutter FH,
Matico R,
Oehlrich D ,
Perrier M,
Ryabchuk P ,
Schepens W,
Sharma S,
Somers M,
Suarez J,
Surkyn M,
Opdenbosch NV,
Verhulst T,
Bottelbergs A
Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity.
Mammoliti O ,
Carbajo R,
Perez-Benito L,
Yu X,
Prieri MLC ,
Bontempi L,
Embrechts S,
Paesmans I,
Bassi M,
Bhattacharya A,
Canellas S ,
De Hoog S,
Demin S ,
Gijsen HJM ,
Hache G,
Jacobs T,
Jerhaoui S ,
Leenaerts J,
Lutter FH,
Mahieu M,
Matico R,
Miller R,
Oehlrich D ,
Perrier M,
Ryabchuk P ,
Schepens W,
Sharma S,
Somers M,
Suarez J,
Surkyn M,
Van Opdenbosch N,
Verhulst T,
Bottelbergs A
(2025) J Med Chem , 68 , 4848 - 4887
,
Carbajo R,
Perez-Benito L,
Yu X,
Prieri MLC ,
Bontempi L,
Embrechts S,
Paesmans I,
Bassi M,
Bhattacharya A,
Canellas S ,
De Hoog S,
Demin S ,
Gijsen HJM ,
Hache G,
Jacobs T,
Jerhaoui S ,
Leenaerts J,
Lutter FH,
Mahieu M,
Matico R,
Miller R,
Oehlrich D ,
Perrier M,
Ryabchuk P ,
Schepens W,
Sharma S,
Somers M,
Suarez J,
Surkyn M,
Van Opdenbosch N,
Verhulst T,
Bottelbergs A
(2025) J Med Chem , 68 , 4848 - 4887
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