EMD-48285

Single-particle
3.6 Å
EMD-48285
3D View Gallery
Deposition: 12/12/2024
Map released: 04/03/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48285

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mi8 summary report (pdf.gz) Map-9mi8 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human PARP1 N-terminal domains bound to nicked DNA

EMD-48285

Single-particle
3.6 Å
EMD-48285
3D View Gallery
Deposition: 12/12/2024
Map released: 04/03/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Full-length human PARP1 bound to nicked DNA and in complex with HPF1 and Timeless fragment
Fitted models: 9mi8

Deposition Authors: Sverzhinsky A , Pascal JM
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation.
Sverzhinsky A , Xue H, Langelier MF , Muniz Correa MV, Del Mundo J, Classen S , Hammel M , Rothenberg E , Pascal JM
(2026) Nat Commun , 17
PUBMED: 41698892
DOI: doi:10.1038/s41467-026-69375-3
ISSN: 2041-1723