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EMD-48284
Cryo-EM structure of SARS-CoV-2 spike protein in complex with neutralizing human antibody WRAIR-2008
EMD-48284
Single-particle3.23 Å
Deposition: 12/12/2024Map released: 20/08/2025
Last modified: 22/10/2025
Sample Organism:
Severe acute respiratory syndrome coronavirus 2,
Homo sapiens
Sample: SARS-CoV-2 spike protein with WRAIR-2008 Fab
Fitted models: 9mi3
Deposition Authors: Jensen JL
,
Thomas PV,
Joyce MG
Sample: SARS-CoV-2 spike protein with WRAIR-2008 Fab
Fitted models: 9mi3
Deposition Authors: Jensen JL
,
Thomas PV,
Joyce MG
First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge.
Dussupt V ,
Jensen JL ,
Thomas PV,
Mendez-Rivera L,
Lal KG,
Zemil McCrea M,
Swafford I,
Hernandez J,
Sankhala RS,
Rao M,
Arora J,
Hajduczki A,
Jian N,
Rees PA,
Showell-De Leon I,
Smith G,
Smith L,
Wasson D,
Schmid A,
Teng IT,
Zhou T ,
Kwong PD ,
Currier JR,
Reiley WW,
Paquin-Proulx D ,
Polonis VR ,
Collins ND,
Michael NL,
Joyce MG ,
Krebs SJ
(2025) Mbio , 16 , e0103625 - e0103625
,
Jensen JL ,
Thomas PV,
Mendez-Rivera L,
Lal KG,
Zemil McCrea M,
Swafford I,
Hernandez J,
Sankhala RS,
Rao M,
Arora J,
Hajduczki A,
Jian N,
Rees PA,
Showell-De Leon I,
Smith G,
Smith L,
Wasson D,
Schmid A,
Teng IT,
Zhou T ,
Kwong PD ,
Currier JR,
Reiley WW,
Paquin-Proulx D ,
Polonis VR ,
Collins ND,
Michael NL,
Joyce MG ,
Krebs SJ
(2025) Mbio , 16 , e0103625 - e0103625
Grant Support:
- Department of Defense (DOD, United States): W81XWH-18-2-0040 (United States)