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EMD-48283
61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab
EMD-48283
Single-particle2.8 Å
Deposition: 12/12/2024Map released: 21/05/2025
Last modified: 13/08/2025
Sample Organism:
Homo sapiens,
Macaca mulatta,
Human immunodeficiency virus 1,
Human immunodeficiency virus
Sample: 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab
Fitted models: 9mi0
Deposition Authors: Phulera S
,
Ozorowski G ,
Ward AB
Sample: 61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab
Fitted models: 9mi0
Deposition Authors: Phulera S
,
Ozorowski G ,
Ward AB
Precise targeting of HIV broadly neutralizing antibody precursors in humans.
Caniels TG ,
Prabhakaran M ,
Ozorowski G ,
MacPhee KJ ,
Wu W ,
van der Straten K ,
Agrawal S ,
Derking R,
Reiss EIMM ,
Millard K ,
Turroja M ,
Desrosiers A ,
Bethony J,
Malkin E ,
Liesdek MH,
van der Veen A,
Klouwens M ,
Snitselaar JL ,
Bouhuijs JH ,
Bronson R ,
Jean-Baptiste J ,
Gajjala S ,
Rikhtegaran Tehrani Z,
Benner A ,
Ramaswami M ,
Duff MO ,
Liu YW ,
Sato AH ,
Kim JY ,
Baken IJL ,
Mendes Silva C ,
Bijl TPL,
van Rijswijk J,
Burger JA,
Cupo A ,
Yasmeen A ,
Phulera S ,
Lee WH ,
Randall Jr KN,
Zhang S ,
Corcoran MM ,
Regadas I,
Sullivan AC,
Brown DM ,
Bohl JA,
Greene KM,
Gao H ,
Yates NL ,
Sawant S ,
Prins JM,
Kootstra NA ,
Kaminsky SM ,
Barin B,
Rahaman F ,
Meller M ,
Philiponis V ,
Laufer DS ,
Lombardo A ,
Mwoga L ,
Shotorbani S ,
Holman D ,
Koup RA ,
Klasse PJ ,
Karlsson Hedestam GB ,
Tomaras GD,
van Gils MJ ,
Montefiori DC ,
McDermott AB ,
Hyrien O ,
Moore JP ,
Wilson IA ,
Ward AB ,
Diemert DJ ,
de Bree GJ ,
Andrews SF ,
Caskey M ,
Sanders RW
(2025) Science , 389 , eadv5572 - eadv5572
,
Prabhakaran M ,
Ozorowski G ,
MacPhee KJ ,
Wu W ,
van der Straten K ,
Agrawal S ,
Derking R,
Reiss EIMM ,
Millard K ,
Turroja M ,
Desrosiers A ,
Bethony J,
Malkin E ,
Liesdek MH,
van der Veen A,
Klouwens M ,
Snitselaar JL ,
Bouhuijs JH ,
Bronson R ,
Jean-Baptiste J ,
Gajjala S ,
Rikhtegaran Tehrani Z,
Benner A ,
Ramaswami M ,
Duff MO ,
Liu YW ,
Sato AH ,
Kim JY ,
Baken IJL ,
Mendes Silva C ,
Bijl TPL,
van Rijswijk J,
Burger JA,
Cupo A ,
Yasmeen A ,
Phulera S ,
Lee WH ,
Randall Jr KN,
Zhang S ,
Corcoran MM ,
Regadas I,
Sullivan AC,
Brown DM ,
Bohl JA,
Greene KM,
Gao H ,
Yates NL ,
Sawant S ,
Prins JM,
Kootstra NA ,
Kaminsky SM ,
Barin B,
Rahaman F ,
Meller M ,
Philiponis V ,
Laufer DS ,
Lombardo A ,
Mwoga L ,
Shotorbani S ,
Holman D ,
Koup RA ,
Klasse PJ ,
Karlsson Hedestam GB ,
Tomaras GD,
van Gils MJ ,
Montefiori DC ,
McDermott AB ,
Hyrien O ,
Moore JP ,
Wilson IA ,
Ward AB ,
Diemert DJ ,
de Bree GJ ,
Andrews SF ,
Caskey M ,
Sanders RW
(2025) Science , 389 , eadv5572 - eadv5572
Grant Support:
- Bill & Melinda Gates Foundation: INV-002916 (United States)