EMD-48227

Single-particle
3.23 Å
EMD-48227
3D View Gallery
Deposition: 09/12/2024
Map released: 05/11/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48227

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9mff summary report (pdf.gz) Map-9mff FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of zebrafish OTOP1 in nanodisc in complex with inhibitor C2.2

EMD-48227

Single-particle
3.23 Å
EMD-48227
3D View Gallery
Deposition: 09/12/2024
Map released: 05/11/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Danio rerio
Sample: zebrafish OTOP1 in MSP2N2 nanodisc
Fitted models: 9mff

Deposition Authors: Burendei B , Ward AB
Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.
Burendei B , Kaplan JP , Orellana GM , Liman ER , Forli S , Ward AB
(2025) Nat Commun , 16 , 9362 - 9362
PUBMED: 41130946
DOI: doi:10.1038/s41467-025-64392-0
ISSN: 2041-1723
Grant Support: