EMD-48111

Single-particle
2.79 Å
EMD-48111
3D View Gallery
Deposition: 30/11/2024
Map released: 08/10/2025
Last modified: 08/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48111

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ek0 summary report (pdf.gz) Map-9ek0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human M5 muscarinic acetylcholine receptor complex with mini-Gq and iperoxo

EMD-48111

Single-particle
2.79 Å
EMD-48111
3D View Gallery
Deposition: 30/11/2024
Map released: 08/10/2025
Last modified: 08/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Rattus norvegicus
Sample: Human M5-miniGq-Gb1g2 complex
Fitted models: 9ek0

Deposition Authors: Burger WAC , Mobbs JI , Thal DM
Cryo-EM reveals an extrahelical allosteric binding site at the M 5 mAChR.
Burger WAC , Mobbs JI , Rana B, Wang J, Joshi K , Gentry PR, Yeasmin M, Venugopal H , Bender AM, Lindsley CW , Miao Y , Christopoulos A , Valant C , Thal DM
(2025) Nat Commun , 16 , 7046 - 7046
PUBMED: 40745154
DOI: doi:10.1038/s41467-025-62212-z
ISSN: 2041-1723