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EMD-48110

Single-particle
2.06 Å
EMD-48110
3D View Gallery
Deposition: 30/11/2024
Map released: 13/08/2025
Last modified: 08/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48110
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ejz summary report (pdf.gz) Map and 9ejz FULL report (pdf.gz)
EMICSS annotations (xml)

Human M5 muscarinic acetylcholine receptor complex with mini-Gq, agonist acetylcholine and positive allosteric modulator VU6007678

EMD-48110

Single-particle
2.06 Å
EMD-48110
3D View Gallery
Deposition: 30/11/2024
Map released: 13/08/2025
Last modified: 08/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama, Rattus norvegicus, Mus musculus
Sample: Human M5-miniGq-Gb1g2 complex
Fitted models: 9ejz

Deposition Authors: Burger WAC , Mobbs JI , Thal DM
Cryo-EM reveals an extrahelical allosteric binding site at the M 5 mAChR.
Burger WAC , Mobbs JI , Rana B, Wang J, Joshi K , Gentry PR, Yeasmin M, Venugopal H , Bender AM, Lindsley CW , Miao Y , Christopoulos A , Valant C , Thal DM
(2025) Nat Commun , 16 , 7046 - 7046
PUBMED: 40745154
DOI: doi:10.1038/s41467-025-62212-z
ISSN: 2041-1723