EMD-48108

Single-particle
2.11 Å
EMD-48108
3D View Gallery
Deposition: 30/11/2024
Map released: 13/08/2025
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-48108

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Focused refinement of M5 Muscarinic acetylcholine receptor in complex with agonist acetylcholine and positive allosteric modulator VU6007678

EMD-48108

Single-particle
2.11 Å
EMD-48108
3D View Gallery
Deposition: 30/11/2024
Map released: 13/08/2025
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human M5-miniGq-Gb1g2 complex

Deposition Authors: Burger WAC , Mobbs JI , Thal DM
Cryo-EM reveals an extrahelical allosteric binding site at the M 5 mAChR.
Burger WAC , Mobbs JI , Rana B, Wang J, Joshi K, Gentry PR, Yeasmin M, Venugopal H, Bender AM, Lindsley CW, Miao Y, Christopoulos A, Valant C, Thal DM
(2025) Nat Commun , 16 , 7046 - 7046
PUBMED: 40745154
DOI: doi:10.1038/s41467-025-62212-z
ISSN: 2041-1723