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EMD-47992
Cannabinoid receptor 1-Gi complex with novel ligand
EMD-47992
Composite mapSingle-particle
3.2 Å
Deposition: 21/11/2024Map released: 30/04/2025
Last modified: 10/09/2025
Sample Organism:
Homo sapiens,
Mus musculus
Sample: Signaling complex of the cannabinoid receptor 1 bound to Gi
Fitted models: 9ego
Deposition Authors: Tummino TA
,
Iliopoulos-Tsoutsouvas C ,
Braz JM ,
O'Brien ES ,
Krishna Kumar K ,
Makriyannis M,
Basbaum AI ,
Shoichet BK
Sample: Signaling complex of the cannabinoid receptor 1 bound to Gi
Fitted models: 9ego
Deposition Authors: Tummino TA
,
Iliopoulos-Tsoutsouvas C ,
Braz JM ,
O'Brien ES ,
Krishna Kumar K ,
Makriyannis M,
Basbaum AI ,
Shoichet BK
Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.
Tummino TA ,
Iliopoulos-Tsoutsouvas C ,
Braz JM ,
O'Brien ES ,
Stein RM,
Craik V ,
Tran NK,
Ganapathy S,
Liu F,
Shiimura Y ,
Tong F ,
Ho TC,
Radchenko DS ,
Moroz YS,
Rosado SR,
Bhardwaj K ,
Benitez J,
Liu Y ,
Kandasamy H,
Normand C,
Semache M,
Sabbagh L ,
Glenn I,
Irwin JJ ,
Kumar KK,
Makriyannis A ,
Basbaum AI ,
Shoichet BK
(2025) Nat Commun , 16 , 2237 - 2237
,
Iliopoulos-Tsoutsouvas C ,
Braz JM ,
O'Brien ES ,
Stein RM,
Craik V ,
Tran NK,
Ganapathy S,
Liu F,
Shiimura Y ,
Tong F ,
Ho TC,
Radchenko DS ,
Moroz YS,
Rosado SR,
Bhardwaj K ,
Benitez J,
Liu Y ,
Kandasamy H,
Normand C,
Semache M,
Sabbagh L ,
Glenn I,
Irwin JJ ,
Kumar KK,
Makriyannis A ,
Basbaum AI ,
Shoichet BK
(2025) Nat Commun , 16 , 2237 - 2237
Grant Support:
- Defense Advanced Research Projects Agency (DARPA): HR0011-19-2-0020 (United States)