EMD-47968
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin candidate 2, open conformation
EMD-47968
Single-particle3.36 Å
Deposition: 19/11/2024Map released: 18/06/2025
Last modified: 10/09/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Protein complex of wild type integrin alpha-5 beta-1 with computationally designed protein NeoNectin candidate 2
Fitted models: 9ef2
Deposition Authors: Werther R
,
Nguyen A ,
Estrada Alamo KA,
Wang X ,
Campbell MG
Sample: Protein complex of wild type integrin alpha-5 beta-1 with computationally designed protein NeoNectin candidate 2
Fitted models: 9ef2
Deposition Authors: Werther R
,
Nguyen A ,
Estrada Alamo KA,
Wang X ,
Campbell MG
De Novo Design of Integrin alpha 5 beta 1 Modulating Proteins to Enhance Biomaterial Properties.
Wang X ,
Guillem-Marti J ,
Kumar S ,
Lee DS ,
Cabrerizo-Aguado D ,
Werther R ,
Alamo KAE ,
Zhao YT ,
Nguyen A ,
Kopyeva I ,
Huang B ,
Li J,
Hao Y,
Li X ,
Brizuela-Velasco A ,
Murray A,
Gerben S ,
Roy A ,
DeForest CA ,
Springer T,
Ruohola-Baker H ,
Cooper JA ,
Campbell MG ,
Manero JM ,
Ginebra MP ,
Baker D
(2025) Adv Mater , 37 , e2500872 - e2500872
,
Guillem-Marti J ,
Kumar S ,
Lee DS ,
Cabrerizo-Aguado D ,
Werther R ,
Alamo KAE ,
Zhao YT ,
Nguyen A ,
Kopyeva I ,
Huang B ,
Li J,
Hao Y,
Li X ,
Brizuela-Velasco A ,
Murray A,
Gerben S ,
Roy A ,
DeForest CA ,
Springer T,
Ruohola-Baker H ,
Cooper JA ,
Campbell MG ,
Manero JM ,
Ginebra MP ,
Baker D
(2025) Adv Mater , 37 , e2500872 - e2500872
Grant Support:
- The Pew Charitable Trusts: NA (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35 GM147414-01 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): P30 CA015704-40; RRID:SCR_022611 (United States)
- Other private: Seattle Cancer Consortium Safeway Inc Pilot Grant