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EMD-47930
Cryo-EM structure of the human KCa3.1/calmodulin channel in complex with Ca2+ and 1,4-dihydropyridine (DHP-103)
EMD-47930
Single-particle3.5 Å
Deposition: 15/11/2024Map released: 16/04/2025
Last modified: 07/05/2025
Sample Organism:
Homo sapiens,
Rattus norvegicus
Sample: Human SK4-CaM channel complex in the presence of calcium.
Fitted models: 9ed1
Deposition Authors: Nam YW, Zhang M
Sample: Human SK4-CaM channel complex in the presence of calcium.
Fitted models: 9ed1
Deposition Authors: Nam YW, Zhang M
Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K Ca 3.1.
Ong ST ,
Nam YW,
Nasburg JA,
Ramanishka A,
Ng XR ,
Zhuang Z,
Goay SSM,
Nguyen HM ,
Singh L,
Singh V,
Rivera A ,
Eyster ME ,
Xu Y,
Alper SL ,
Wulff H ,
Zhang M ,
Chandy KG
(2025) PNAS , 122 , e2425494122 - e2425494122
,
Nam YW,
Nasburg JA,
Ramanishka A,
Ng XR ,
Zhuang Z,
Goay SSM,
Nguyen HM ,
Singh L,
Singh V,
Rivera A ,
Eyster ME ,
Xu Y,
Alper SL ,
Wulff H ,
Zhang M ,
Chandy KG
(2025) PNAS , 122 , e2425494122 - e2425494122
Grant Support:
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): 4R33 NS101182-03 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): 1R15 NS130420-01A1 (United States)
- American Heart Association: 23AIREA1039423 (United States)
- American Heart Association: 24CDA1260237 (United States)