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EMD-47928

Single-particle
3.89 Å
EMD-47928
3D View Gallery
Deposition: 15/11/2024
Map released: 20/08/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47928
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ecz summary report (pdf.gz) Map and 9ecz FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of SARS-CoV-2 spike protein in complex with human neutralizing antibody WRAIR-2008 (focused refinement of NTD and WRAIR-2008)

EMD-47928

Single-particle
3.89 Å
EMD-47928
3D View Gallery
Deposition: 15/11/2024
Map released: 20/08/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, Homo sapiens
Sample: WRAIR-2008 antibody Fab bound to the N-terminal domain of the spike glycoprotein (focused refinement)
Fitted models: 9ecz

Deposition Authors: Jensen JL , Thomas PV, Joyce MG
First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge.
Dussupt V , Jensen JL , Thomas PV, Mendez-Rivera L, Lal KG, Zemil McCrea M, Swafford I, Hernandez J, Sankhala RS, Rao M, Arora J, Hajduczki A, Jian N, Rees PA, Showell-De Leon I, Smith G, Smith L, Wasson D, Schmid A, Teng IT, Zhou T , Kwong PD , Currier JR, Reiley WW, Paquin-Proulx D , Polonis VR , Collins ND, Michael NL, Joyce MG , Krebs SJ
(2025) Mbio , 16 , e0103625 - e0103625
PUBMED: 40882161
DOI: doi:10.1128/mbio.01036-25
ISSN: 2150-7511