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EMD-47927
CryoEM Structure Of Respiratory Syncytial Virus Polymerase in complex with Novel Non-Nucleoside Inhibitor Compound 16
EMD-47927
Single-particle2.79 Å
Deposition: 15/11/2024Map released: 24/09/2025
Last modified: 24/09/2025
Sample Organism:
human respiratory syncytial virus,
synthetic construct
Sample: CryoEM map of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor compound 16
Fitted models: 9ecv
Deposition Authors: Yin Y, Tran MT
,
Yu X,
Jonckers T,
Carney C
Sample: CryoEM map of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor compound 16
Fitted models: 9ecv
Deposition Authors: Yin Y, Tran MT
,
Yu X,
Jonckers T,
Carney C
DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
Carney SM,
Grosse S,
Yin Y,
Tran MT ,
Kalin JH ,
Jacoby E,
Fung A,
Simmons N,
Xie X,
Bhaumik A,
Carbajo RJ,
Piassek M,
Miller R,
Hu L,
Lemmens C,
Lutter FH,
Pieters S,
Rombouts G ,
Vetrano I,
Oehlrich D ,
Tomaso S,
Lozada K,
Garcia MO,
Anson B,
De Bruyn S,
Smith-Monroy C,
Neefs JM,
Conceicao-Neto N,
Kesteleyn B ,
Fino R ,
Stoops B,
van Vlijmen H ,
Patrick AN,
Yu X,
Wong V,
Krosky DJ ,
Abeywickrema P,
Ortiz-Meoz RF,
Mason SW,
Jin Z,
Sharma S,
Jonckers THM
(2025) J Med Chem , 68 , 6407 - 6430
,
Kalin JH ,
Jacoby E,
Fung A,
Simmons N,
Xie X,
Bhaumik A,
Carbajo RJ,
Piassek M,
Miller R,
Hu L,
Lemmens C,
Lutter FH,
Pieters S,
Rombouts G ,
Vetrano I,
Oehlrich D ,
Tomaso S,
Lozada K,
Garcia MO,
Anson B,
De Bruyn S,
Smith-Monroy C,
Neefs JM,
Conceicao-Neto N,
Kesteleyn B ,
Fino R ,
Stoops B,
van Vlijmen H ,
Patrick AN,
Yu X,
Wong V,
Krosky DJ ,
Abeywickrema P,
Ortiz-Meoz RF,
Mason SW,
Jin Z,
Sharma S,
Jonckers THM
(2025) J Med Chem , 68 , 6407 - 6430
Grant Support:
- Not funded: (United States)