EMD-47927

Single-particle
2.79 Å
EMD-47927
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Deposition: 15/11/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47927
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ecv summary report (pdf.gz) Map and 9ecv FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM Structure Of Respiratory Syncytial Virus Polymerase in complex with Novel Non-Nucleoside Inhibitor Compound 16

EMD-47927

Single-particle
2.79 Å
EMD-47927
3D View Gallery
Deposition: 15/11/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: human respiratory syncytial virus, synthetic construct
Sample: CryoEM map of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor compound 16
Fitted models: 9ecv

Deposition Authors: Yin Y, Tran MT, Yu X, Jonckers T, Carney C
DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
Carney SM, Grosse S, Yin Y, Tran MT, Kalin JH, Jacoby E, Fung A, Simmons N, Xie X, Bhaumik A, Carbajo RJ, Piassek M, Miller R, Hu L, Lemmens C, Lutter FH, Pieters S, Rombouts G, Vetrano I, Oehlrich D, Tomaso S, Lozada K, Garcia MO, Anson B, De Bruyn S, Smith-Monroy C, Neefs JM, Conceicao-Neto N, Kesteleyn B, Fino R, Stoops B, van Vlijmen H, Patrick AN, Yu X, Wong V, Krosky DJ, Abeywickrema P, Ortiz-Meoz RF, Mason SW, Jin Z, Sharma S, Jonckers THM
(2025) J Med Chem , 68 , 6407 - 6430
PUBMED: 40042938
DOI: doi:10.1021/acs.jmedchem.4c02906
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: