EMD-47889

Single-particle
3.3 Å
EMD-47889
3D View Gallery
Deposition: 13/11/2024
Map released: 29/01/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47889

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ebs summary report (pdf.gz) Map-9ebs FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of USP1-UAF1-Ubiquitin in complex with TNG348

EMD-47889

Single-particle
3.3 Å
EMD-47889
3D View Gallery
Deposition: 13/11/2024
Map released: 29/01/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: USP1-UAF1-Ub complex with TNG348
Fitted models: 9ebs

Deposition Authors: Whittington DA
Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency.
Simoneau A , Pratt CB , Wu HJ , Rajeswaran SS , Comer CG , Sudsakorn S , Zhang W , Liu S , Meier SR , Choi AH , Khendu T , Stowe H , Shen B , Whittington DA , Chen Y , Yu Y , Mallender WD , Feng T , Andersen JN , Maxwell JP , Throner S
(2025) Mol.Cancer Ther. , 24 , 678 - 691
PUBMED: 39886906
DOI: doi:10.1158/1535-7163.MCT-24-0515
ISSN: 1538-8514
Grant Support: