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EMD-47889
Cryo-EM structure of USP1-UAF1-Ubiquitin in complex with TNG348
EMD-47889
Single-particle3.3 Å
Deposition: 13/11/2024Map released: 29/01/2025
Last modified: 17/09/2025
Sample Organism:
Homo sapiens
Sample: USP1-UAF1-Ub complex with TNG348
Fitted models: 9ebs
Deposition Authors: Whittington DA
Sample: USP1-UAF1-Ub complex with TNG348
Fitted models: 9ebs
Deposition Authors: Whittington DA
Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency.
Simoneau A ,
Pratt CB ,
Wu HJ ,
Rajeswaran SS ,
Comer CG ,
Sudsakorn S ,
Zhang W ,
Liu S ,
Meier SR ,
Choi AH ,
Khendu T ,
Stowe H ,
Shen B ,
Whittington DA ,
Chen Y ,
Yu Y ,
Mallender WD ,
Feng T ,
Andersen JN ,
Maxwell JP ,
Throner S
(2025) Mol.Cancer Ther. , 24 , 678 - 691
,
Pratt CB ,
Wu HJ ,
Rajeswaran SS ,
Comer CG ,
Sudsakorn S ,
Zhang W ,
Liu S ,
Meier SR ,
Choi AH ,
Khendu T ,
Stowe H ,
Shen B ,
Whittington DA ,
Chen Y ,
Yu Y ,
Mallender WD ,
Feng T ,
Andersen JN ,
Maxwell JP ,
Throner S
(2025) Mol.Cancer Ther. , 24 , 678 - 691
Grant Support:
- Other private: (United States)