EMD-47793

Single-particle
3.24 Å
EMD-47793
3D View Gallery
Deposition: 08/11/2024
Map released: 11/02/2026
Last modified: 11/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47793

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9e9e summary report (pdf.gz) Map-9e9e FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 (LBD-TMD) in complex with anti-miR 17 oligonucleotide RGLS4326

EMD-47793

Single-particle
3.24 Å
EMD-47793
3D View Gallery
Deposition: 08/11/2024
Map released: 11/02/2026
Last modified: 11/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus
Sample: GluA2-y2 + oligo RGLS 4326
Fitted models: 9e9e

Deposition Authors: Yen LY, Gangwar SP , Yelshanskaya MV, Sobolevsky AI
The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.
Valencia T, Yen LY, Berman C, Vincent T, Davis S, Varrone F , Huang J, Mastroianni J, Carlson M, Owen T, Kamel A, Drygin D, Kinberger GA, Gangwar SP , Yelshanskaya MV, Ridley J, Kirby R, Alvarez J, Lakhia R , Patel V , Sobolevsky AI , Lee EC
(2025) Nat Commun , 16 , 10762 - 10762
PUBMED: 41315228
DOI: doi:10.1038/s41467-025-65799-5
ISSN: 2041-1723