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EMD-47494

Single-particle
2.53 Å
EMD-47494
3D View Gallery
Deposition: 23/10/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47494
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9e3q summary report (pdf.gz) Map and 9e3q FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the mouse P2X7 receptor in the apo closed state

EMD-47494

Single-particle
2.53 Å
EMD-47494
3D View Gallery
Deposition: 23/10/2024
Map released: 24/09/2025
Last modified: 24/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Membrane protein
Fitted models: 9e3q

Deposition Authors: Oken AC , Turcu AL , Vazquez S , Mansoor SE
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor.
Oken AC , Turcu AL , Tzortzini E, Georgiou K, Nagel J , Westermann FG , Barniol-Xicota M, Seidler J, Kim GR, Lee SD, Nicke A , Kim YC, Muller CE , Kolocouris A , Vazquez S , Mansoor SE
(2025) Nat Commun , 16 , 8283 - 8283
PUBMED: 40954149
DOI: doi:10.1038/s41467-025-62643-8
ISSN: 2041-1723