EMD-47364
CryoEM structure of inducible Lysine decarboxylase from Hafnia alvei L-hydrazino-Lysine analog at 2.04 Angstrom resolution
EMD-47364
Single-particle2.0 Å
Deposition: 18/10/2024Map released: 04/06/2025
Last modified: 04/06/2025
Sample Organism:
Hafnia alvei ATCC 51873
Sample: Inducible Lysine decarboxylase from Hafnia alvei with bound L-hydrazino-lysine inhibitor
Fitted models: 9e0o
Deposition Authors: Duhoo Y
,
Desfosses A ,
Gutsche I ,
Doukov TI,
Berkowitz DB
Sample: Inducible Lysine decarboxylase from Hafnia alvei with bound L-hydrazino-lysine inhibitor
Fitted models: 9e0o
Deposition Authors: Duhoo Y
,
Desfosses A ,
Gutsche I ,
Doukov TI,
Berkowitz DB
alpha-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery?
Baine JM ,
Duhoo Y ,
Doukov T ,
Desfosses A ,
Bisello G ,
Beio ML ,
Bauer O ,
Perduca M ,
Bacia-Verloop M ,
Bertoldi M ,
Phillips RS ,
Gutsche I ,
Berkowitz DB
(2025) ACS Catal , 15 , 8204 - 8218
,
Duhoo Y ,
Doukov T ,
Desfosses A ,
Bisello G ,
Beio ML ,
Bauer O ,
Perduca M ,
Bacia-Verloop M ,
Bertoldi M ,
Phillips RS ,
Gutsche I ,
Berkowitz DB
(2025) ACS Catal , 15 , 8204 - 8218
Grant Support:
- French National Research Agency: ANR-10-INBS-0005-02 (France)
- French National Research Agency: ANR-17-EURE-0003 (France)
- National Science Foundation (NSF, United States): NSF-2102705 (United States)
- National Science Foundation (NSF, United States): NSF-2400333 (United States)