EMD-47339

Single-particle
3.27 Å
EMD-47339
3D View Gallery
Deposition: 17/10/2024
Map released: 05/02/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47339

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dzv summary report (pdf.gz) Map-9dzv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 in the E1 state

EMD-47339

Single-particle
3.27 Å
EMD-47339
3D View Gallery
Deposition: 17/10/2024
Map released: 05/02/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer
Fitted models: 9dzv

Deposition Authors: Duan HD, Li H
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK , Puumala E, Fiebig AA, Hu G, Yiu B, Chou S, Bian Z, Choi Y, Guo ABY, Wang W, Sun S, Robbins N, Averette AF, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Coombes BK, Cowen LE, Heitman J, Li H, Wright GD
(2026) Cell , 189 , 620
PUBMED: 41478284
DOI: doi:10.1016/j.cell.2025.11.036
ISSN: 1097-4172