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EMD-47339

Single-particle
3.27 Å
EMD-47339
3D View Gallery
Deposition: 17/10/2024
Map released: 05/02/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47339
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9dzv summary report (pdf.gz) Map and 9dzv FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 in the E1 state

EMD-47339

Single-particle
3.27 Å
EMD-47339
3D View Gallery
Deposition: 17/10/2024
Map released: 05/02/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer
Fitted models: 9dzv

Deposition Authors: Duan HD, Li H
Butyrolactol A is a phospholipid flippase inhibitor that potentiates the bioactivity of caspofungin against resistant fungi.
Chen X , Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK, Puumala E, Hu G, Yiu B, Chou S, Bian Z, Guo ABY, Sun S, Robbins N, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Cowen LE, Heitman J , Li H , Wright GD
(2025) bioRxiv
PUBMED: 39829750
DOI: doi:10.1101/2025.01.06.630955
ISSN: 2692-8205