EMD-47155
The cryo-EM structure of apo KBTBD4
EMD-47155
Single-particle3.83 Å
Deposition: 30/09/2024Map released: 27/11/2024
Last modified: 19/03/2025
Sample Organism:
Homo sapiens
Sample: KBTBD4 dimer
Fitted models: 9dtg
Deposition Authors: Xie X
,
Mao H,
Liau B,
Zheng N
Sample: KBTBD4 dimer
Fitted models: 9dtg
Deposition Authors: Xie X
,
Mao H,
Liau B,
Zheng N
UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Yeo MJR ,
Zhang O ,
Xie X ,
Nam E,
Payne NC ,
Gosavi PM ,
Kwok HS ,
Iram I ,
Lee C ,
Li J,
Chen NJ ,
Nguyen K ,
Jiang H ,
Wang ZA ,
Lee K ,
Mao H,
Harry SA,
Barakat IA,
Takahashi M ,
Waterbury AL ,
Barone M ,
Mattevi A ,
Carr SA ,
Udeshi ND ,
Bar-Peled L ,
Cole PA ,
Mazitschek R ,
Liau BB ,
Zheng N
(2025) Nature , 639 , 232 - 240
,
Zhang O ,
Xie X ,
Nam E,
Payne NC ,
Gosavi PM ,
Kwok HS ,
Iram I ,
Lee C ,
Li J,
Chen NJ ,
Nguyen K ,
Jiang H ,
Wang ZA ,
Lee K ,
Mao H,
Harry SA,
Barakat IA,
Takahashi M ,
Waterbury AL ,
Barone M ,
Mattevi A ,
Carr SA ,
Udeshi ND ,
Bar-Peled L ,
Cole PA ,
Mazitschek R ,
Liau BB ,
Zheng N
(2025) Nature , 639 , 232 - 240
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)