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EMD-47043

Single-particle
6.1 Å
EMD-47043
3D View Gallery
Deposition: 17/09/2024
Map released: 01/10/2025
Last modified: 19/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47043
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9dnn summary report (pdf.gz) Map and 9dnn FULL report (pdf.gz)
EMICSS annotations (xml)

Insulin receptor in complex with both insulin and de novo designed site-2 binder "S2B".

EMD-47043

Single-particle
6.1 Å
EMD-47043
3D View Gallery
Deposition: 17/09/2024
Map released: 01/10/2025
Last modified: 19/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens, synthetic construct
Sample: Insulin receptor bound with both insulin and designed site-2 binder S2B.
Fitted models: 9dnn

Deposition Authors: Bai XC
Tuning insulin receptor signaling using de novo-designed agonists.
Wang X, Cardoso S, Cai K, Venkatesh P, Hung A, Ng M, Hall C, Coventry B, Lee DS, Chowhan R, Gerben S, Li J, An W, Hon M, Gao M, Liao YC, Accili D, Choi E, Bai XC, Baker D
(2025) Mol Cell , 85 , 4064
PUBMED: 41086805
DOI: doi:10.1016/j.molcel.2025.09.020
ISSN: 1097-2765
ASTM: MOCEFL