EMD-47042
Structure of rat beta-arrestin 1 bound to allosteric inhibitor
EMD-47042
Single-particle3.47 Å
Deposition: 17/09/2024Map released: 22/01/2025
Last modified: 15/07/2026
Sample Organism:
Rattus norvegicus,
Homo sapiens
Sample: Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-BRIL Fab
Fitted models: 9dnm
Deposition Authors: Pakharukova N, Kahsai AW, Masoudi A, Lefkowitz RJ
Sample: Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-BRIL Fab
Fitted models: 9dnm
Deposition Authors: Pakharukova N, Kahsai AW, Masoudi A, Lefkowitz RJ
Small-molecule modulation of beta-arrestins.
Kahsai AW,
Pakharukova N,
Kwon HY,
Shah KS,
Del Real CT,
Shreiber BN,
Liang-Lin JG,
Shim PJ,
Lee MA,
Ngo VA,
Schwalb AM,
Pham U,
Chundi A,
Jiang H,
Flores-Espinoza E,
Liu S,
Nibley PC,
Bassford DK,
Hahn H,
Kunzle CA,
Thomas BN,
Kim J,
Zhou Y,
Wang J,
Zhang X,
Smith JS,
Rein LAM,
Thomsen ARB,
Shenoy SK,
Rajagopal S,
Shi L,
Ahn S,
Rockman HA,
Masoudi A,
Lefkowitz RJ
(2026) Nature
(2026) Nature
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL016037 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): T32HL007101 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL16037-45S1 (United States)
- Human Frontier Science Program (HFSP): LT000174/2018 (France)
- European Molecular Biology Organization (EMBO): ALTF 1071-2017 (European Union)