EMD-47042
Structure of rat beta-arrestin 1 bound to allosteric inhibitor
EMD-47042
Single-particle3.47 Å
Deposition: 17/09/2024Map released: 22/01/2025
Last modified: 02/09/2026
Sample Organism:
Rattus norvegicus,
Homo sapiens
Sample: Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-BRIL Fab
Fitted models: 9dnm
Deposition Authors: Pakharukova N, Kahsai AW
,
Masoudi A,
Lefkowitz RJ
Sample: Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-BRIL Fab
Fitted models: 9dnm
Deposition Authors: Pakharukova N, Kahsai AW
,
Masoudi A,
Lefkowitz RJ
Small-molecule modulation of beta-arrestins.
Kahsai AW ,
Pakharukova N,
Kwon HY ,
Shah KS ,
Del Real CT ,
Shreiber BN ,
Liang-Lin JG ,
Shim PJ ,
Lee MA ,
Ngo VA ,
Schwalb AM,
Pham U ,
Chundi A ,
Jiang H ,
Flores-Espinoza E ,
Liu S,
Nibley PC,
Bassford DK,
Hahn H ,
Kunzle CA,
Thomas BN ,
Kim J,
Zhou Y ,
Wang J,
Zhang X,
Smith JS,
Rein LAM,
Thomsen ARB ,
Shenoy SK ,
Rajagopal S ,
Shi L ,
Ahn S ,
Rockman HA ,
Masoudi A,
Lefkowitz RJ
(2026) Nature , 656 , 770 - 779
,
Pakharukova N,
Kwon HY ,
Shah KS ,
Del Real CT ,
Shreiber BN ,
Liang-Lin JG ,
Shim PJ ,
Lee MA ,
Ngo VA ,
Schwalb AM,
Pham U ,
Chundi A ,
Jiang H ,
Flores-Espinoza E ,
Liu S,
Nibley PC,
Bassford DK,
Hahn H ,
Kunzle CA,
Thomas BN ,
Kim J,
Zhou Y ,
Wang J,
Zhang X,
Smith JS,
Rein LAM,
Thomsen ARB ,
Shenoy SK ,
Rajagopal S ,
Shi L ,
Ahn S ,
Rockman HA ,
Masoudi A,
Lefkowitz RJ
(2026) Nature , 656 , 770 - 779
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL016037 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): T32HL007101 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL16037-45S1 (United States)
- Human Frontier Science Program (HFSP): LT000174/2018 (France)
- European Molecular Biology Organization (EMBO): ALTF 1071-2017 (European Union)