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EMD-47016
Cryo-EM structure of IMPDH2 bound to IMP and GAD
EMD-47016
Single-particle1.82 Å
Deposition: 14/09/2024Map released: 27/11/2024
Last modified: 25/12/2024
Sample Organism:
Homo sapiens
Sample: Ternary complex of IMPDH2 bound to IMP and GAD
Fitted models: 9dmu
Deposition Authors: Chen YJ
,
Li B,
Parada LF
Sample: Ternary complex of IMPDH2 bound to IMP and GAD
Fitted models: 9dmu
Deposition Authors: Chen YJ
,
Li B,
Parada LF
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma.
Chen YJ ,
Iyer SV ,
Hsieh DC ,
Li B,
Elias HK ,
Wang T,
Li J,
Ganbold M,
Lien MC,
Peng YC,
Xie XP ,
Jayewickreme CD,
van den Brink MRM ,
Brady SF ,
Lim SK,
Parada LF
(2024) Nature , 636 , 466 - 473
,
Iyer SV ,
Hsieh DC ,
Li B,
Elias HK ,
Wang T,
Li J,
Ganbold M,
Lien MC,
Peng YC,
Xie XP ,
Jayewickreme CD,
van den Brink MRM ,
Brady SF ,
Lim SK,
Parada LF
(2024) Nature , 636 , 466 - 473
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA210100 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA196519-01 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA008748 (United States)