EMD-47006

Single-particle
3.35 Å
EMD-47006
3D View Gallery
Deposition: 13/09/2024
Map released: 18/06/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-47006

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dmi summary report (pdf.gz) Map-9dmi FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of the C-terminal half of LRRK2 bound to RN277 (Type-II inhibitor)

EMD-47006

Single-particle
3.35 Å
EMD-47006
3D View Gallery
Deposition: 13/09/2024
Map released: 18/06/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: C-terminal half of LRRK2 bound to RN277
Fitted models: 9dmi

Deposition Authors: Sanz-Murillo M, Leschziner A
Type II kinase inhibitors that target Parkinson's disease-associated LRRK2.
Raig ND , Surridge KJ , Sanz-Murillo M, Dederer V , Kramer A , Schwalm MP , Lattal NM, Elson L , Chatterjee D, Mathea S , Hanke T , Leschziner AE , Reck-Peterson SL , Knapp S
(2025) Sci Adv , 11 , eadt2050 - eadt2050
PUBMED: 40465731
DOI: doi:10.1126/sciadv.adt2050
ISSN: 2375-2548
Grant Support: