Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-47002
Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold
EMD-47002
Helical reconstruction3.2 Å
Deposition: 13/09/2024Map released: 23/04/2025
Last modified: 05/11/2025
Sample Organism:
Homo sapiens
Sample: Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold
Fitted models: 9dme
Deposition Authors: Xu X
,
Angera JI,
Rajewski HB,
Jiang W ,
Del Valle RJ
Sample: Type 3 KD-mxyl filament of miniature tau macrocycle derived from 4R tauopathic fold
Fitted models: 9dme
Deposition Authors: Xu X
,
Angera JI,
Rajewski HB,
Jiang W ,
Del Valle RJ
Macrocyclic beta-arch peptides that mimic the structure and function of disease-associated tau folds.
Angera IJ ,
Xu X ,
Rajewski BH ,
Hallinan GI,
Zhang X,
Ghetti B,
Vidal R ,
Jiang W ,
Del Valle JR
(2025) Nat Chem , 17 , 865 - 874
,
Xu X ,
Rajewski BH ,
Hallinan GI,
Zhang X,
Ghetti B,
Vidal R ,
Jiang W ,
Del Valle JR
(2025) Nat Chem , 17 , 865 - 874
Grant Support:
- National Institutes of Health/National Institute on Aging (NIH/NIA): R01 AG074570 (United States)
- National Science Foundation (NSF, United States): CHE2109008 (United States)