Electron Microscopy Data Bank

EMD-46979

Single-particle
2.7 Å

3D View Gallery

Deposition: 11/09/2024
Map released: 12/03/2025
Last modified: 03/09/2025

Overview 3D View Sample Experiment Validation Additional data Links

EMD-46979

PKD2 ion channel, R638C variant

EMD-46979

Single-particle
2.7 Å
EMD-46979

3D View Gallery

Deposition: 11/09/2024
Map released: 12/03/2025
Last modified: 03/09/2025

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Homo sapiens
Sample: PKD2 R638C variant protomer
Fitted models: 9dli

Deposition Authors: Esarte Palomero O, DeCaen PG

Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction.

Palomero OE, Guadarrama E , DeCaen PG
(2025) PNAS , 122 , e2421362122 - e2421362122

PUBMED: 40504156
DOI: doi:10.1073/pnas.2421362122
ISSN: 1091-6490
ASTM: PNASA6

Secondary citations:

Pettersen EF, Goddard TD, Huang CC, Meng EC, Couch GS, Croll TI, Morris JH & Ferrin TE. (2021) UCSF ChimeraX: Structure visualization for researchers, educators, and developers. Protein Sci, 30, 70 - 82
& Croll TI. (2018) ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Acta Crystallogr D Struct Biol, 74, 519 - 530

Grant Support:

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01 DK123463-01 (United States)
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01 DK131118-01 (United States)
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): F32DK137477-01A1 (United States)
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): TL1DK132769 (United States)

EMD-46979

EMD-46979

Archive Files (Depositor)

Validation (wwPDB)

EMDB Annotations

EMDB Files

PKD2 ion channel, R638C variant

EMD-46979