EMD-46888

Single-particle
3.1 Å
EMD-46888
3D View Gallery
Deposition: 04/09/2024
Map released: 04/03/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-46888

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dhx summary report (pdf.gz) Map-9dhx FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

human Argonaute-2 R315V/H316A - miR-122 in complex with a fully complementary target

EMD-46888

Single-particle
3.1 Å
EMD-46888
3D View Gallery
Deposition: 04/09/2024
Map released: 04/03/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: human Argonaute-2 R315V/H316A - miR-122 in complex with a fully complementary target
Fitted models: 9dhx

Deposition Authors: Sarkar S , Gebert LFR , MacRae IJ
Catalytic activation of human Argonaute 2 requires RNA duplex deformation.
Sarkar S , Gebert LFR , MacRae IJ
(2026) Nat Struct Mol Biol , 33 , 1214 - 1223
PUBMED: 42342972
DOI: doi:10.1038/s41594-026-01840-5
ISSN: 1545-9985