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EMD-46855
Cryo-EM structure of NLRP3 complex with Compound C
EMD-46855
Single-particle3.76 Å
Deposition: 03/09/2024Map released: 25/12/2024
Last modified: 22/01/2025
Sample Organism:
Homo sapiens
Sample: N-terminal MBP Fusion of NLRP3 Lacking the PYD Domain
Fitted models: 9dh3
Deposition Authors: Matico R, Grauwen K, Van Gool M, Muratore EM, Yu X
,
Abdiaj I,
Adhikary S,
Adriaensen I,
Aranzazu GM,
Alcazar J,
Bassi M,
Brisse E ,
Canellas S ,
Chaudhuri S,
Chauhan D,
Delgado F,
Dieguez-Vazquez A,
Du Jardin M,
Eastham V,
Finley M ,
Jacobs T,
Keustermans K,
Kuhn R,
Llaveria J ,
Leenaerts J,
Linares ML,
Martin ML,
Martinez C,
Miller R,
Munoz FM,
Nooyens A,
Perez LB,
Perrier M,
Pietrak B,
Serre J ,
Sharma S,
Somers M,
Suarez J,
Tresadern G,
Trabanco AA ,
Van den Bulck D,
Van Hauwermeiren F,
Varghese T ,
Vega JA,
Youssef SA,
Edwards MJ,
Oehlrich D,
Van Opdenbosch N
Sample: N-terminal MBP Fusion of NLRP3 Lacking the PYD Domain
Fitted models: 9dh3
Deposition Authors: Matico R, Grauwen K, Van Gool M, Muratore EM, Yu X
,
Abdiaj I,
Adhikary S,
Adriaensen I,
Aranzazu GM,
Alcazar J,
Bassi M,
Brisse E ,
Canellas S ,
Chaudhuri S,
Chauhan D,
Delgado F,
Dieguez-Vazquez A,
Du Jardin M,
Eastham V,
Finley M ,
Jacobs T,
Keustermans K,
Kuhn R,
Llaveria J ,
Leenaerts J,
Linares ML,
Martin ML,
Martinez C,
Miller R,
Munoz FM,
Nooyens A,
Perez LB,
Perrier M,
Pietrak B,
Serre J ,
Sharma S,
Somers M,
Suarez J,
Tresadern G,
Trabanco AA ,
Van den Bulck D,
Van Hauwermeiren F,
Varghese T ,
Vega JA,
Youssef SA,
Edwards MJ,
Oehlrich D,
Van Opdenbosch N
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.
Matico R,
Grauwen K,
Chauhan D,
Yu X ,
Abdiaj I,
Adhikary S,
Adriaensen I,
Aranzazu GM,
Alcazar J,
Bassi M,
Brisse E ,
Canellas S ,
Chaudhuri S,
Delgado F,
Dieguez-Vazquez A,
Du Jardin M,
Eastham V,
Finley M ,
Jacobs T,
Keustermans K,
Kuhn R,
Llaveria J ,
Leenaerts J,
Linares ML,
Martin ML,
Martin-Perez R ,
Martinez C,
Miller R,
Munoz FM,
Muratore ME,
Nooyens A,
Perez-Benito L,
Perrier M,
Pietrak B,
Serre J ,
Sharma S,
Somers M,
Suarez J,
Tresadern G,
Trabanco AA ,
Van den Bulck D,
Van Gool M,
Van Hauwermeiren F,
Varghese T ,
Vega JA,
Youssef SA,
Edwards MJ,
Oehlrich D,
Van Opdenbosch N
(2025) Embo Mol Med , 17 , 54 - 84
,
Abdiaj I,
Adhikary S,
Adriaensen I,
Aranzazu GM,
Alcazar J,
Bassi M,
Brisse E ,
Canellas S ,
Chaudhuri S,
Delgado F,
Dieguez-Vazquez A,
Du Jardin M,
Eastham V,
Finley M ,
Jacobs T,
Keustermans K,
Kuhn R,
Llaveria J ,
Leenaerts J,
Linares ML,
Martin ML,
Martin-Perez R ,
Martinez C,
Miller R,
Munoz FM,
Muratore ME,
Nooyens A,
Perez-Benito L,
Perrier M,
Pietrak B,
Serre J ,
Sharma S,
Somers M,
Suarez J,
Tresadern G,
Trabanco AA ,
Van den Bulck D,
Van Gool M,
Van Hauwermeiren F,
Varghese T ,
Vega JA,
Youssef SA,
Edwards MJ,
Oehlrich D,
Van Opdenbosch N
(2025) Embo Mol Med , 17 , 54 - 84
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