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EMD-46793
Cryo-EM structures of full-length integrin alphaIIbbeta3 in native lipids complexed with modified tirofiban
EMD-46793
Single-particle4.1 Å
Deposition: 29/08/2024Map released: 16/10/2024
Last modified: 30/10/2024
Sample Organism:
Homo sapiens
Sample: full length integrin alphaIIbbeta3
Fitted models: 9deq
Deposition Authors: Adair B, Xiong JP, Yeager M, Arnaout MA
Sample: full length integrin alphaIIbbeta3
Fitted models: 9deq
Deposition Authors: Adair B, Xiong JP, Yeager M, Arnaout MA
Platelet integrin alpha IIb beta 3 plays a key role in a venous thrombogenesis mouse model.
Adair BD,
Field CO ,
Alonso JL,
Xiong JP,
Deng SX,
Ahn HS,
Mashin E,
Clish CB ,
van Agthoven J,
Yeager M,
Guo Y ,
Tess DA,
Landry DW,
Poncz M,
Arnaout MA
(2024) Nat Commun , 15 , 8612 - 8612
,
Alonso JL,
Xiong JP,
Deng SX,
Ahn HS,
Mashin E,
Clish CB ,
van Agthoven J,
Yeager M,
Guo Y ,
Tess DA,
Landry DW,
Poncz M,
Arnaout MA
(2024) Nat Commun , 15 , 8612 - 8612
Grant Support:
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL141366 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): DK088327 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM084545 (United States)