Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-46758
Cryo-EM structure of neutralizing murine antibody WS.HSV-1.24 in complex with HSV-1 glycoprotein B trimer gB-Ecto.516P.531E
EMD-46758
Single-particle3.1 Å
Deposition: 27/08/2024Map released: 10/09/2025
Last modified: 12/11/2025
Sample Organism:
Mus musculus,
Human alphaherpesvirus 1
Sample: WS.HSV-1.24 Fab in complex with HSV-1 gB trimer
Fitted models: 9dd6
Deposition Authors: Roark RS, Shapiro LS, Kwong PD
Sample: WS.HSV-1.24 Fab in complex with HSV-1 gB trimer
Fitted models: 9dd6
Deposition Authors: Roark RS, Shapiro LS, Kwong PD
Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B.
Roark RS,
Schaub AJ,
Shi W,
Wang M,
Bahna FA,
Becker JE,
Biju A ,
Chong S,
Du H,
Guo Y ,
Hong H ,
Katsamba PS,
Mannepalli SM,
Olia AS,
Ou L ,
Rubin SK,
Sabo Y ,
Suleiman M ,
Wells ML,
Zhang B,
Cheng C ,
Glasgow A ,
Ho DD,
Huang Y ,
Pierson TC,
Rawi R ,
Zhou T ,
Shapiro L ,
Kwong PD
(2025) Nat Microbiol , 10 , 2966 - 2980
,
Chong S,
Du H,
Guo Y ,
Hong H ,
Katsamba PS,
Mannepalli SM,
Olia AS,
Ou L ,
Rubin SK,
Sabo Y ,
Suleiman M ,
Wells ML,
Zhang B,
Cheng C ,
Glasgow A ,
Ho DD,
Huang Y ,
Pierson TC,
Rawi R ,
Zhou T ,
Shapiro L ,
Kwong PD
(2025) Nat Microbiol , 10 , 2966 - 2980
Grant Support: