EMD-46699

Single-particle
2.8 Å
EMD-46699
3D View Gallery
Deposition: 22/08/2024
Map released: 17/12/2025
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-46699

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dav summary report (pdf.gz) Map-9dav FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

STING oligomer bound to cGAMP and STG2 in the presence of PI4P

EMD-46699

Single-particle
2.8 Å
EMD-46699
3D View Gallery
Deposition: 22/08/2024
Map released: 17/12/2025
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: STING oligomer bound to its ligand cGAMP, a synthetic activator named STG2, in the presence of Cholesteryl hemisuccinate and PI4P
Fitted models: 9dav

Deposition Authors: Li J , Zhang X , Bai X
Regulation of STING activation by phosphoinositide and cholesterol.
Li J , Tan JX , Chen ZJ , Zhang X , Bai XC
(2026) Nature , 652 , 499 - 507
PUBMED: 41639452
DOI: doi:10.1038/s41586-025-10076-0
ISSN: 1476-4687
ASTM: NATUAS