EMD-46694

Single-particle
2.6 Å
EMD-46694
3D View Gallery
Deposition: 22/08/2024
Map released: 17/12/2025
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-46694

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9dan summary report (pdf.gz) Map-9dan FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

STING oligomer bound to PI(4,5)P2

EMD-46694

Single-particle
2.6 Å
EMD-46694
3D View Gallery
Deposition: 22/08/2024
Map released: 17/12/2025
Last modified: 22/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: STING oligomer bound to its ligand cGAMP, a synthetic activator named STG2, Cholesteryl hemisuccinate and PI(4,5)P2
Fitted models: 9dan

Deposition Authors: Li J , Zhang X , Bai X
Regulation of STING activation by phosphoinositide and cholesterol.
Li J , Tan JX , Chen ZJ , Zhang X , Bai XC
(2026) Nature , 652 , 499 - 507
PUBMED: 41639452
DOI: doi:10.1038/s41586-025-10076-0
ISSN: 1476-4687
ASTM: NATUAS